Dwell 02
It holds,
then clears.
Held on the surface through the repair window — then it clears.
occupancy × dwell × interval
Binding 03
One molecule.
Two receptors.
A dual-receptor agonist that engages A2A and A1 on the ocular surface.
A2A + A1 · adenosine GPCRs
Cascade 04
The signal
propagates.
A2A raises cAMP through PKA — the relay behind both downstream effects.
Gαs → AC → cAMP → PKA
Resolution 05
Two axes,
one molecule.
Bicarbonate rebuilds the mucin gel; the inflamed macrophage shifts M1 → M2.
CFTR · HCO₃⁻ → mucin · M1→M2
Calm 06
The surface
calms.
Osmolarity falls, the tear film stabilizes, the surface recovers.
osmolarity · 316 → 301 mOsm/L*